South Africa, who has already lost the series, will rest Steyn and Jacques Kallis for the 3rd and final ODI against Pakistan at Centurion on Coming Saturday.
South Africa Fast Bowler Steyn has a mild side strain while all-rounder Kallis has a badly sprained little finger.
South Africa starts a 3-match 50-over series against India next Thursday followed by 2 tests.
Steyn and Jacques will play a key role in the series against India so we felt it was necessary to take precautionary measures so that they are in prime condition, team manager Dr Mohammed Moosajee said on Thursday.
Pakistan leads the ODI encounter 2-0, their 1st bilateral series win over South Africa.